The Human Brain on Psilocybin, aka Magic Mushrooms

Researchers elevate psilocybin research by scanning their own brains while tripping

Katrina Paulson
8 min readAug 4, 2024

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A type of psilocybin mushrooms — Photo by Igor Omilaev on Unsplash

Since at least 3,000 BCE, our species has intentionally consumed plants to induce psychoactive and psychedelic experiences, typically for spiritual and healing purposes. Still, such practices continue today and have expanded to include modern drugs such as LSD, MDMA (ecstasy), and ketamine — many of which are done recreationally rather than ritualistically.

The effects of psychedelics, in particular, capture the attention of more than party-goers, though. Modern researchers have continued to support the idea that when experienced safely, psychedelic experiences can relieve mental distress, such as depression and post-traumatic stress disorder (PTSD). Scientists have studied the compounds and effects of psychedelics like magic mushrooms for decades, but now research is showing precisely how they affect the brain.

Psilocybin

Psilocybin (4-phosphoryl oxy-N, N-dimethyltryptamine) is one of the most widely distributed natural hallucinogenic compounds on Earth, found in over 180 species of mushrooms worldwide. Mushrooms containing psilocybin are commonly referred to as “magic mushrooms” or simply “shrooms” which are typically dried or crushed…

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Katrina Paulson

I wonder about humanity, questions with no answers, and new discoveries. Then I write about them here and on substack! https://curiousadventure.substack.com